Tarleton State University	Department of Biological Sciences
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Max G. Sanderford, Ph.D. Assistant Professor MS, Baylor University PhD, University of Texas Health Science Center E-mail: sanderford@tarleton.edu Tel: 254-968-9162 Office: 213J Science Bldg

General Biology 1204: Plant Emphasis

General Biology 1214:  Animal Emphasis

Human Anatomy and Physiology (BIOL2194)

Histology (BIOL3024)

Animal Physiology (BIOL4604)

Animal Physiology (BIOL4614)

My  research  focuses on mechanisms by which circulating factors or hormones  modulate neural regulation of arterial blood pressure.  The peptide, angiotensin II, while playing a very important role in fluid and electrolyte balance, is also implicated in the pathogenesis of several forms of experimental and clincal hypertension.  At least part of the hypertensive actions of angiotensin II result from central neural actions that increase sympathetic neural outflow to the periphery.

It has been observed that the incidence of hypertension is lower in premenopausal women compared to age-matched men.  This observation suggests that female reproductive hormones such as estrogen are "protective" against the development of hypertension.  Studies are currently underway in my laboratory to determine if estrogen "protects" against the development of angiotensin II-dependent hypertension by acting on the brain to decrease the activity of the sympathetic nervous system, thereby decreasing arterial blood pressure.

Student Research Opportunities

Publications

Peer Reviewed Journals:
 
• Kim, S. W.,  B. P. Yu, M. G. Sanderford, and J. T. Herlihy.  Dietary restriction modulates the norepinephrine content and uptake of the heart and cardiac synaptosomes.  P.S.E.B.M. 207:43-47, 1994.
• Liu, J., H. Murakami, M. G. Sanderford, V. S. Bishop, and I. H. Zucker.  Angiotensin II and baroreflex function in rabbits with CHF and lesions of the area postrema. Am. J. Physiol. 277(Heart and Circulation)1999.
• Bishop, V.S. and M.G. Sanderford,  Angiotensin II modulation of the arterial baroreflex: role of the area postrema.  Clin Exp Pharmacol Physiol. 2000 May-Jun;27(5-6):428-31.
• Sanderford, M.G. and V. S. Bishop.  Angiotensin II acutely attenuates range of arterial baroreflex control of renal sympathetic nerve activity. Am J Physiol Heart Circ Physiol. 2000 Oct;279(4):H1804-12.
• Sanderford, M.G. and V. S. Bishop.  Central mechanisms of acute ANG II modulation of arterial baroreflex control of renal sympathetic nerve activity.  Am J Physiol Heart Circ Physiol. 2002 May;282(5):H1592-602.
• Sanderford, M.G. and V.S. Bishop.  Role of alpha-2 adrenergic receptors in mediating acute angiotensin II modulation of arterial baroreflex function.  [In Preparation].


Chapters:
 

• Bishop, V.S. and M.G. Sanderford.  Vasopressin and the Heart.  In Contemporary Endocrinology:  Hormones and the Heart in Health and Disease. L. Share (ed.) Humana Press,Totowa, New Jersey pp. 103-114, 1999.


Abstracts:

• Sanderford, M.G. and V.S. Bishop.  Involvement of opiates in the regulation of arginine vasopressin (AVP) release.  FASEB J. 8:A823, #4774, 1994.
• Sanderford, M.G., M. Hay and V.S. Bishop. C-FOS antisense in the nucleus tractus solitarius alters blood pressure response to chronic arginine vasopressin infusion.  Neurosci. Abstracts.  21:#353.15, 1995.
• Sanderford, M.G. and V.S. Bishop.  Attenuation of peak renal sympathetic nerve activity by angiotensin II to baroreceptor unloading is abolished by area postrema lesion.  Neurosci. Abstracts. 23:723, #284.17, 1997.
• Sanderford, M.G., G.M. Toney and V.S. Bishop.  Attenuation of peak renal sympathetic nerve activity (pRSNA) by angiotensin II during baroreceptor unloading is abolished by alpha-2 antagonism. FASEB J. 12:A53, #310, 1998.
• Sanderford, M.G. and V.S. Bishop.  Decerebration prevents attenuation of the sympathetic response to baroreceptor unloading by angiotensin II. FASEB J., 1999.
• Sanderford, M.G., Guy, C., Hay, M., Hasser, E.M., and V.S. Bishop. 17-ß estradiol enhances reflex bradycardia produced by elevating blood pressure with angiotensin II.  FASEB J., 1999.
• Dawson, A.,  Lesley,N.,  Manning, D.  Sanders, J. and M. G. Sanderford. 17-ß Estradiol Reduces Sympathetic Neural Support of Blood Pressure in Angiotensin II Dependent Hypertension.  Beta Beta Beta Texas Convention, 2001

Personal Interests

Camping, hiking, fly fishing, hunting, reading, hanging out with my family and friends.